GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs881827 | 1 | rs881827 | chr21:48019868 | C21orf56 | chr21:47581063-47604373:- | -0.25 | -4.03 | 6.69E-5 | Lymphocyte counts |
| BLCA | cis | rs882367 | 1 | rs882367 | chr17:59494574 | C17orf82 | chr17:59489112-59490641:+ | 0.2 | 4.4 | 1.39E-5 | Sitting height ratio |
| BLCA | cis | rs4660306 | 1 | rs882803 | chr1:45976147 | CCDC163P | chr1:45960581-45965646:- | -0.74 | -14.99 | 2.75E-40 | Homocysteine levels |
| BLCA | cis | rs1577917 | 1 | rs884841 | chr6:86680300 | SNHG5 | chr6:86386726-86388451:- | -0.5 | -8.85 | 3.22E-17 | Response to antipsychotic treatment |
| BLCA | cis | rs889312 | 1 | rs889312 | chr5:56031884 | C5orf35 | chr5:56205103-56213010:+ | 0.3 | 4.75 | 2.85E-6 | Breast cancer (early onset);Breast cancer |
| BLCA | cis | rs9876781 | 1 | rs898225 | chr3:48413179 | TREX1 | chr3:48501186-48509043:+ | 0.19 | 3.84 | 0.000145 | Longevity |
| BLCA | cis | rs7112513 | 1 | rs900012 | chr11:116966435 | PCSK7 | chr11:117075789-117102811:- | -0.43 | -5.32 | 1.74E-7 | Protein quantitative trait loci |
| BLCA | cis | rs2243480 | 1 | rs906134 | chr7:65444288 | CCT6P1 | chr7:65216092-65228661:+ | 0.33 | 4.47 | 1.05E-5 | Diabetic kidney disease |
| BLCA | cis | rs4763879 | 1 | rs917911 | chr12:9905851 | CLECL1 | chr12:9868457-9885860:- | 0.23 | 5.66 | 2.9E-8 | Type 1 diabetes |
| BLCA | cis | rs1671400 | 1 | rs919586 | chr8:13174671 | LONRF1 | chr8:12579406-12612992:- | 0.35 | 5.14 | 4.31E-7 | Obesity-related traits |
| BLCA | cis | rs60843830 | 1 | rs9213 | chr2:218386 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.72 | 2.65E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs9876781 | 1 | rs922075 | chr3:48489398 | TREX1 | chr3:48501186-48509043:+ | 0.2 | 4.04 | 6.42E-5 | Longevity |
| BLCA | cis | rs925098 | 1 | rs925098 | chr4:17919811 | LCORL | chr4:17844844-18023385:- | 0.28 | 4.19 | 3.53E-5 | Height |
| BLCA | cis | rs10461617 | 1 | rs9283717 | chr5:56078659 | C5orf35 | chr5:56205103-56213010:+ | 0.73 | 11.23 | 1.75E-25 | Type 2 diabetes |
| BLCA | cis | rs7615952 | 1 | rs9289275 | chr3:125648659 | ALG1L | chr3:125648118-125655882:- | -0.38 | -6.49 | 2.65E-10 | Blood pressure (smoking interaction) |